反应详情

To 0.57 g of 2-(5-Chloro-thiophen-2-ylmethyl)-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester in 3 ml of methanol were added 0.08 g of lithium hydroxide and 1 ml of water. The reaction was heated to reflux for 1 h. The reaction mixture was adjusted to pH 5 by the addition of 2M aqueous hydrochloric acid and was extracted with ethyl acetate three times. The combined organic phases were dried over sodium sulphate and concentrated in vacuo. The product precipitated after treatment with diethylether and 0.30 g (55%) of 2-(5-Chloro-thiophen-2-ylmethyl)-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid were obtained.

1. temperatureThe reaction was heated
2. temperatureto reflux for 1 h
3. extractionwas extracted with ethyl acetate three times
4. dry with materialThe combined organic phases were dried over sodium sulphate
5. concentrationconcentrated in vacuo
6. customThe product precipitated after treatment with diethylether