2-Morpholinoethylamine → 2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-(2-morpholin-4-ylethyl)-1,3-thiazole-4-carboxamide

HRID 1750367Notes

Reaction equation

HRID 1750367 reaction equation
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([C:22]([OH:24])=O)[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[O:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][NH2:33])[CH2:27][CH2:26]1>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([C:22]([NH:33][CH2:32][CH2:31][N:28]3[CH2:29][CH2:30][O:25][CH2:26][CH2:27]3)=[O:24])[N:21]=2)[CH:7]=[N:6]1)([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 867212022-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazole-4-carboxylic acid

Product 1

HCID 867212062-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-(2-morpholin-4-ylethyl)-1,3-thiazole-4-carboxamide

Procedure

Using 2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazole-4-carboxylic acid and 2-morpholinoethanamine and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-a2fbec3857814bf48e8f9fe4d9ea8fce
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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