Hydrochloric Acid → HCID 86721282, compound

HRID 1750440Notes

Reaction equation

HRID 1750440 reaction equation
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[C:8]([C:18]2[S:19][CH:20]=[C:21](/[CH:23]=[CH:24]/[C:25]([O:27]CC)=[O:26])[N:22]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>C1COCC1.CO>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=2)=[C:8]([C:18]2[S:19][CH:20]=[C:21](/[CH:23]=[CH:24]/[C:25]([OH:27])=[O:26])[N:22]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86721281HCID 86721281, compound

Product 1

HCID 86721282HCID 86721282, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To a mixed solution of the compound (200 mg, 0.49 mmol) obtained in step 4 in THF (2 mL) and methanol (2 mL) was added 1N aqueous sodium hydroxide solution (0.972 ml, 0.97 mmol) at room temperature, and the mixture was stirred at 60° C. for 3 hr. The reaction mixture was cooled to room temperature, and 1N hydrochloric acid was added until the mixture became pH 2-3. The mixture was extracted with ethyl acetate, the organic layer was dried, and the solvent was evaporated under reduced pressure to give (E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid (180.7 mg, 0.471 mmol, 97%) as a white powder.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. extractionThe mixture was extracted with ethyl acetate
  3. customthe organic layer was dried
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-97437364c72e4918b7c7bd3e263b2d98
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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