Hydrochloric Acid → HCID 118025227, compound

HRID 1750553Notes

Reaction equation

HRID 1750553 reaction equation
[F:1][C:2]1([F:29])[CH2:6][CH:5]([NH:7]C(=O)OC(C)(C)C)[CH:4]([NH:15][C:16](=[O:28])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:23]2[N:27]=[CH:26][CH:25]=[N:24]2)[CH2:3]1.[ClH:30]>O1CCOCC1>[ClH:30].[NH2:7][CH:5]1[CH2:6][C:2]([F:29])([F:1])[CH2:3][CH:4]1[NH:15][C:16](=[O:28])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]1[N:24]=[CH:25][CH:26]=[N:27]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118025580HCID 118025580, compound

Product 1

HCID 118025227HCID 118025227, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl N-{4,4-difluoro-2-[2-(2H-1,2,3-triazol-2-yl)benzamido]cyclopentyl}carbamate (640 mg, 1.57 mmol) in dry 1,4-dioxane (5 ml) was added HCl in 1,4-dioxane (4M, 3.9 ml, 15.71 mmol). The reaction was stirred at room temperature for 6 hours then concentrated in vacuo and azeotropically distilled with toluene to afford the title compound.

Workup

  1. concentrationthen concentrated in vacuo
  2. distillationazeotropically distilled with toluene

Sources & evidence

ORD record
ord-be3e7b2c7964451697d7f58fa2c4b1ca
Source dataset
uspto-grants-2015_10
Patent number
US09156829B2

Reaction notes

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