Hydrochloric Acid → HCID 66652304, compound

HRID 1750943Notes

Reaction equation

HRID 1750943 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:35]=[CH:34][CH:33]=[CH:32][C:6]=1[CH2:7][N:8]1[C:12](=[O:13])[C:11]2([CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[N:10]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:9]1)=[O:4].Cl>O1CCOCC1>[O:13]=[C:12]1[C:11]2([CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[N:10]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:9][N:8]1[CH2:7][C:6]1[CH:32]=[CH:33][CH:34]=[CH:35][C:5]=1[C:3]([O:2][CH3:1])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046786HCID 58046786, compound

Product 1

HCID 66652304HCID 66652304, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(2-(methoxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.12 g, 0.25 mmol) was added 4M solution of HCl in dioxane (2.5 mL). After stirring at room temperature for 90 minutes, the reaction mixture was concentrated in vacuo to obtain methyl 2-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-c73f6d1680a5413496d9d17c09ad9934
Source dataset
uspto-grants-2015_10
Patent number
US09156840B2

Reaction notes

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