Hydrochloric Acid → HCID 66652293, compound

HRID 1750956Notes

Reaction equation

HRID 1750956 reaction equation
[CH3:1][N:2]([CH3:40])[C:3](=[O:39])[CH2:4][O:5][C:6]([C:8]1[CH:9]=[C:10]([CH:36]=[CH:37][CH:38]=1)[CH2:11][N:12]1[C:16](=[O:17])[C:15]2([CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)[N:14]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:13]1)=[O:7].Cl>O1CCOCC1>[O:17]=[C:16]1[C:15]2([CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)[N:14]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:13][N:12]1[CH2:11][C:10]1[CH:9]=[C:8]([CH:38]=[CH:37][CH:36]=1)[C:6]([O:5][CH2:4][C:3]([N:2]([CH3:1])[CH3:40])=[O:39])=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046698HCID 58046698, compound

Product 1

HCID 66652293HCID 66652293, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(3-((2-(dimethylamino)-2-oxoethoxy)carbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.26 g, 0.47 mmol) was added 4M solution of HCl in dioxane (5 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain 2-(dimethylamino)-2-oxoethyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-80fb2e9676794c63afa54d4c00a89c3c
Source dataset
uspto-grants-2015_10
Patent number
US09156840B2

Reaction notes

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