Hydrochloric Acid → HCID 86708810, compound

HRID 1751716Notes

Reaction equation

HRID 1751716 reaction equation
[CH3:1][O:2][C:3]([NH:5][C@H:6]([C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1)[C:7]([N:9]1[CH2:13][C@@H:12]([CH3:14])[CH2:11][C@H:10]1[C:15]1[NH:16][C:17]([C:20]2[CH:33]=[C:32]3[O:34][CH2:35][C:29]4[C:30]5[C:31]3=[C:22]([CH2:23][O:24][C:25]=5[CH:26]=[C:27]([C:36]3[NH:40][C:39]([C@@H:41]5[CH2:45][C@H:44]([CH2:46][O:47][CH3:48])[CH2:43][N:42]5C(OC(C)(C)C)=O)=[N:38][CH:37]=3)[CH:28]=4)[CH:21]=2)=[CH:18][N:19]=1)=[O:8])=[O:4].Cl>C(O)C>[CH3:48][O:47][CH2:46][C@@H:44]1[CH2:43][NH:42][C@H:41]([C:39]2[NH:40][C:36]([C:27]3[CH:26]=[C:25]4[O:24][CH2:23][C:22]5[C:31]6[C:30]4=[C:29]([CH2:35][O:34][C:32]=6[CH:33]=[C:20]([C:17]4[NH:16][C:15]([C@@H:10]6[CH2:11][C@H:12]([CH3:14])[CH2:13][N:9]6[C:7](=[O:8])[C@H:6]([NH:5][C:3](=[O:4])[O:2][CH3:1])[C:56]6[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=6)=[N:19][CH:18]=4)[CH:21]=5)[CH:28]=3)=[CH:37][N:38]=2)[CH2:45]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69675376HCID 69675376, compound

Product 1

HCID 86708810HCID 86708810, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of (2S,4S)-tert-butyl 2-(5-(7-(2-((2S,4S)-1-((R)-2-(methoxycarbonylamino)-2-phenylacetyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-5-yl)-5,10-dihydrochromeno[5,4,3-cde]chromen-2-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate (245 mg) and 5 mL 1.25N HCl in ethanol was stirred at room temperature overnight, then at 60° C. for 1 hour, then concentrated to an orange solid as an HCl salt (180 mg) that was used without further purification.

Workup

  1. waitat 60° C. for 1 hour
  2. concentrationconcentrated to an orange solid as an HCl salt (180 mg) that
  3. customwas used without further purification

Sources & evidence

ORD record
ord-94f3eb0c5611446c8353c414f883253c
Source dataset
uspto-grants-2015_10
Patent number
US09156823B2

Reaction notes

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