反应详情

温度

120 °C

4 g (II) are placed in 15 ml dimethylformamide, then 4.5 ml diisopropylethylamine are added followed by 2.5 ml 3-fluorophenylamine. The reaction mixture is heated to 120° C. until there is no further reaction then cooled and evaporated down. The residue is mixed with water. The product is extracted with dichloromethane and purified by chromatography (silica gel, petroleum ether/ethyl acetate 80/20 to 60/40). 2.6 g (III-7) are obtained in the form of a solid. Analytical HPLC (method A): RT=3.27 min

1. customno further reaction
2. temperaturethen cooled
3. customevaporated down
4. additionThe residue is mixed with water
5. extractionThe product is extracted with dichloromethane
6. custompurified by chromatography (silica gel, petroleum ether/ethyl acetate 80/20 to 60/40)
7. custom2.6 g (III-7) are obtained in the form of a solid