Methylamine → n-Methyl-3-nitropyridin-4-amine

HRID 1751803Notes

Reaction equation

HRID 1751803 reaction equation
CO[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10].[CH3:12][NH2:13]>C(O)C>[CH3:12][NH:13][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 3558324-Methoxy-3-nitropyridine

Product 1

HCID 556016n-Methyl-3-nitropyridin-4-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.36 g 4-methoxy-3-nitro-pyridine and 2.33 ml methylamine (40% in water) are refluxed in 25 ml of ethanol for 3 h. Then the reaction mixture is evaporated to dryness. 2.3 g product are obtained in the form of a solid.

Workup

  1. customThen the reaction mixture is evaporated to dryness

Sources & evidence

ORD record
ord-026394b9529e4ab6851935addf9df61c
Source dataset
uspto-grants-2015_10
Patent number
US09161927B2

Reaction notes

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