Pyrazole → 1-(4-Methoxyphenyl)-1H-pyrazole

HRID 1751937Notes

Reaction equation

HRID 1751937 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11](Br)=[CH:10][CH:9]=1>>[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 77304-Bromoanisole

Product 1

HCID 122381311-(4-Methoxyphenyl)-1H-pyrazoleYield 80%

Procedure

Following General Procedure A (125° C., 24 hours), 1H-pyrazole (102 mg, 1.5 mmol) is coupled with 4-methoxybromobenzene (1.0 mmol). The crude product is purified by flash chromatography on silica gel to provide the desired product (80% GC yield).

Workup

  1. customThe crude product is purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-7f9fe7ef13804a338a1087a33d7872fb
Source dataset
uspto-grants-2015_10
Patent number
US09162953B2

Reaction notes

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