Iodoethane → HCID 87391898, compound

HRID 1751971Notes

Reaction equation

HRID 1751971 reaction equation
CC1C=C2C(=CC=1)N(O[S:12](O)(=O)=O)C(=O)C2.S[C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=O)[CH2:21]2.[CH2:28](I)[CH3:29].P([O-])([O-])(O)=O>CO>[CH2:28]([C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=[S:12])[CH2:21]2)[CH3:29]

Participants

6

Reactant 4

HCID 6340IodoethaneHCID 3681305Hydrogen phosphateHCID 11983903794521-56-5HCID 67419345HCID 67419345, compound

Product 1

HCID 87391898HCID 87391898, compoundYield 92.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Under reaction conditions analogous to the preparation of 5-methylsulfoxyoxindole, alkylation of 5-mercaptooxindole 1.99 g (12.05 mmol) with ethyl iodide 1.35 mL (16.7 mmol) in aqueous methanol at 50° C. in the presence of hydrogen phosphate provided 2.152 g of 5-ethylthiooxindole (92.5%).

Workup

  1. customUnder reaction conditions

Sources & evidence

ORD record
ord-63e128f906964c3eb3445ef94f3838ab
Source dataset
uspto-grants-2015_10
Patent number
US09162981B2

Reaction notes

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