Sodium hydride → HCID 57762546, compound

HRID 1752069Notes

Reaction equation

HRID 1752069 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:4][CH:3]=1.Br[CH2:16][CH:17]=[C:18]([CH3:20])[CH3:19].[H-].[Na+]>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:16][CH:17]=[C:18]([CH3:20])[CH3:19])[C:9]2[N:10]=[CH:11][CH:12]=[CH:13][N:14]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 700922-Butene, 1-bromo-3-methyl-HCID 57762548N-(4-iodophenyl)pyrimidin-2-amine

Product 1

HCID 57762546HCID 57762546, compoundYield 94.9%

Procedure

In the same manner as in Reference Example 13, N-(4-iodophenyl)pyrimidin-2-amine (150 mg) and 1-bromo-3-methyl-2-butene (90 mg) were reacted in the presence of sodium hydride to obtain N-(4-iodophenyl)-N-(3-methyl-2-butenyl)pyrimidin-2-amine (175 mg).

Sources & evidence

ORD record
ord-ee290c55e5d444778d7e46a602641093
Source dataset
uspto-grants-2015_10
Patent number
US09162988B2

Reaction notes

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