Sodium hydride → HCID 57762541, compound

HRID 1752070Notes

Reaction equation

[I:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:4][CH:3]=1.[CH:15]1([CH2:18]Br)[CH2:17][CH2:16]1.[H-].[Na+]>>[CH:15]1([CH2:18][N:8]([C:5]2[CH:4]=[CH:3][C:2]([I:1])=[CH:7][CH:6]=2)[C:9]2[N:10]=[CH:11][CH:12]=[CH:13][N:14]=2)[CH2:17][CH2:16]1

Participants

Reactant 3

HCID 24758Sodium hydride

HCID 81503Bromomethylcyclopropane

HCID 57762548N-(4-iodophenyl)pyrimidin-2-amine

Product 1

HCID 57762541HCID 57762541, compoundYield 91.4%

Procedure

In the same manner as in Reference Example 13, N-(4-iodophenyl)pyrimidin-2-amine (150 mg) and cyclopropylmethyl bromide (82 mg) were reacted in the presence of sodium hydride to obtain N-(cyclopropylmethyl)-N-(4-iodophenyl)pyrimidin-2-amine (162 mg).

Sources & evidence

ORD record: ord-b5e70677fb2f4d7daca1bbd33a70fda5
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09162988B2

Reaction notes

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