Hydrochloric Acid → HCID 67773047, compound

HRID 1752157Notes

Reaction equation

HRID 1752157 reaction equation
[CH3:1][N:2]([CH3:18])[NH:3][C:4]1[C:5]2[CH:16]=[CH:15][N:14]([CH3:17])[C:6]=2[N:7]=[C:8]([NH:10][CH2:11][CH2:12][CH3:13])[N:9]=1.[ClH:19]>O>[ClH:19].[CH3:18][N:2]([CH3:1])[NH:3][C:4]1[C:5]2[CH:16]=[CH:15][N:14]([CH3:17])[C:6]=2[N:7]=[C:8]([NH:10][CH2:11][CH2:12][CH3:13])[N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57378349HCID 57378349, compound

Product 1

HCID 67773047HCID 67773047, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N,N-dimethyl-N′-(2-n-propylamino-7-methyl-pyrrolo[2,3 d]pyrimidin-4-yl)-hydrazine (100 mg, 0.4 mmol) was dissolved in H2O (5 mL) and 0.5 M aqueous HCl solution (1 mL) and the solution was lyophilized to yield N,N-dimethyl-N′-(2-n-propylamino-7-methyl-pyrrolo[2,3-d]pyrimidin-4-yl)-hydrazine hydrochloride (110 mg) as a yellow oil. LCMS (ESI) m/z=249 (M+H)+. 1H NMR (500 MHz, MeOD) δ (ppm) 6.92 (d, J=4.0 Hz, 1H), 6.50 (d, J=3.0 Hz, 1H), 3.66 (s, 3H), 3.45 (t, J=7.5 Hz, 2H), 2.79 (s, 6H), 1.67-1.72 (m, 2H), 1.01-1.04 (m, 3H).

Sources & evidence

ORD record
ord-363e30503f0a421d88db740cf26ffba5
Source dataset
uspto-grants-2015_10
Patent number
US09162992B2

Reaction notes

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