Hydrochloric Acid → Hydrochloric Acid

HRID 1752282Notes

Reaction equation

HRID 1752282 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([CH:12]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13]3)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]1=[O:24].[ClH:25].O1CCOCC1>C(Cl)Cl>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([CH:12]3[CH2:16][CH2:15][NH:14][CH2:13]3)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]1=[O:24].[ClH:25]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67480094HCID 67480094, compound

Product 2

HCID 313Hydrochloric AcidHCID 58171532HCID 58171532, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A stirred solution of tert-butyl 3-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)pyrrolidine-1-carboxylate (1 mg) in CH2Cl2 (2 mL) was treated with 4 M HCl in dioxane (1 mL, 4 mmol). The mixture was stirred at rt for 3 h and concentrated to leave 1-methyl-6-(pyrrolidin-3-yl)quinolin-2(1H)-one as its HCl salt (1 mg). LC-MS Method 1 tR=1.48 min, m/z=229.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-2616b9608d2a4262b049096e9ed0690e
Source dataset
uspto-grants-2015_10
Patent number
US09163012B2

Reaction notes

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