Hydrochloric Acid → Sodium Chloride

HRID 1752481Notes

Reaction equation

HRID 1752481 reaction equation
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[CH:7][N:6]=1)=[O:4].[OH-].[Na+:19].[ClH:20].C1(C)C=CC=CC=1>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[N:9]=1.[Cl-:20].[Na+:19]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 14798Sodium HydroxideHCID 68108403HCID 68108403, compound

Product 2

HCID 5234Sodium ChlorideHCID 68107873HCID 68107873, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-amino-5-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester (400 mg, 1.59 mmol) in THF (20 ml) was added 1N sodium hydroxide (2.5 ml, 2.5 mmol) and the mixture was stirred at room temperature over night. To the mixture were added 1N HCl (2.39 ml, 2.39 mmol) after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with sodium chloride as an off-white solid. The mixture was used for coupling reactions without further purification.

Workup

  1. additionwas added
  2. customthe solvents were evaporated

Sources & evidence

ORD record
ord-b5fafcc233284d3a82fbbd10cd74bc58
Source dataset
uspto-grants-2015_10
Patent number
US09163011B2

Reaction notes

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