Hydrochloric Acid → HCID 86689164, compound

HRID 1752484Notes

Reaction equation

HRID 1752484 reaction equation
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([O:12][CH2:13][CH2:14][F:15])=[CH:7][N:6]=1)=[O:4].[OH-].[Na+].Cl>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[C:8]([O:12][CH2:13][CH2:14][F:15])[N:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86689163HCID 86689163, compound

Product 1

HCID 86689164HCID 86689164, compoundYield 128.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-amino-5-(2-fluoro-ethoxy)-pyrazine-2-carboxylic acid methyl ester (176 mg, 0.818 mmol) in THF (6.8 ml) was added a solution of 1M NaOH (900 μl, 0.900 mmol). The reaction was stirred at it for 48 h. A solution of 1M HCl (1096 μL, 1.096 mmol) was added, the mixture was evaporated to dryness and then co-evaporated with toluene to give a light purple solid (212 mg). The crude material was used directly for the coupling reactions.

Workup

  1. customthe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-6d42224c63024663a6100fe5d26835a8
Source dataset
uspto-grants-2015_10
Patent number
US09163011B2

Reaction notes

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