Toluene → HCID 68109996, compound

HRID 1752494Notes

Reaction equation

HRID 1752494 reaction equation
C([O:5][C:6]([C:8]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:11]([CH:17]([F:19])[F:18])=[CH:10][N:9]=1)=[O:7])(C)(C)C.C1(C)C=CC=CC=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[F:19][CH:17]([F:18])[C:11]1[CH:12]=[C:13]([N+:14]([O-:16])=[O:15])[C:8]([C:6]([OH:7])=[O:5])=[N:9][CH:10]=1

Participants

5

Reactant 2

HCID 1140TolueneHCID 68110177HCID 68110177, compound

Product 1

HCID 68109996HCID 68109996, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

In a mixture of 5 ml DCM and 2.5 ml TFA was dissolved 345 mg (1.26 mmol) 5-difluoromethyl-3-nitro-pyridine-2-carboxylic acid tert-butyl ester and the reaction mixture was stirred for 4 h. Toluene was added and the solvents were evaporated to provide the title compound as colorless solid.

Workup

  1. customthe solvents were evaporated

Sources & evidence

ORD record
ord-ad09ccdb4d5a4661b37e1ab9c2e6c5b3
Source dataset
uspto-grants-2015_10
Patent number
US09163011B2

Reaction notes

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