Potassium Carbonate → HCID 24274903, compound

HRID 1752512Notes

Reaction equation

HRID 1752512 reaction equation
C1(C=[N:8][CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)C=CC=CC=1.Br[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:18][CH2:17][N:13]2[CH2:12][CH2:11][CH:10]([CH2:9][NH2:8])[CH2:15][CH2:14]2)=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 844271-(2-Bromoethyl)-4-methoxybenzene2×HCID 11820173N-Benzylidene(piperidin-4-yl)methanamine2×

Product 1

HCID 24274903HCID 24274903, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of N-[phenylmethylidene]-1-(piperidin-4-yl)methanamine (compound iii; 0.158 moles; 31.9 g), prepared as described in WO2004/101548 in absolute ethanol (70 ml), 1-(2-bromoethyl)-4-methoxybenzene (compound iv; 0.237 moles; 32.7 g) and potassium carbonate were added.

Sources & evidence

ORD record
ord-7068fb79f45449d1a3ba540040acc96a
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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