Hydrochloric Acid → HCID 178511937, compound

HRID 1752930Notes

Reaction equation

HRID 1752930 reaction equation
[OH:1][C:2]1[C:7]([C:8]2[NH:12][C:11]3[CH:13]=[CH:14][C:15]([C:17]([NH2:19])=[NH:18])=[CH:16][C:10]=3[N:9]=2)=[CH:6][C:5]([C:20]2[NH:24][N:23]=[N:22][N:21]=2)=[CH:4][C:3]=1[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31][NH2:32])[C:26]=1[OH:33].C(N(CC)CC)C.[O-:41][C:42]#[N:43].[K+].Cl>CO>[OH:1][C:2]1[C:7]([C:8]2[NH:12][C:11]3[CH:13]=[CH:14][C:15]([C:17]([NH2:19])=[NH:18])=[CH:16][C:10]=3[N:9]=2)=[CH:6][C:5]([C:20]2[NH:24][N:23]=[N:22][N:21]=2)=[CH:4][C:3]=1[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31][NH:32][C:42]([NH2:43])=[O:41])[C:26]=1[OH:33]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 11378442Potassium cyanateHCID 178511936HCID 178511936, compound

Product 1

HCID 178511937HCID 178511937, compoundYield 8.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

2-(2,2′-Dihydroxy-5-(1H-tetrazol-5-yl)-3′-aminomethylbiphenyl-3-yl]-1H-benzoimidazole-5-carboxamidine (0.2 g 0.2 mmol), prepared as in Example 7, was dissolved in methanol (10 mL). The solution was treated with triethylamine (0.2 mL, 1.5 mmol) and then potassium cyanate (0.09 g, 1.1 mmol aqueous solution, 0.5 mL) was added in 3 portions over 1 hour. 1N hydrochloric acid (5 mL) was added and the mixture was stirred at 50° C. over 3 days. Drying afforded crude product, which was subjected to purification by reverse phase HPLC to give 2-(2,2′-dihydroxy-5-(1H-tetrazol-5-yl)-3′-ureidomethylbiphenyl-3-yl]-1H-benzoimidazole-5-carboxamidine (0.008 g) as a brown solid. LCMS calcd. 484.47, obsrvd. (M+H) 485.1, (M−H) 483.1.

Workup

  1. customDrying
  2. customafforded crude product, which
  3. customwas subjected to purification by reverse phase HPLC

Sources & evidence

ORD record
ord-7b686c042d9b483c90f7dc37eead0658
Source dataset
uspto-grants-2015_10
Patent number
US09162986B2

Reaction notes

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