huagongshe.com
HRID1753056

反应详情

EQUATION

反应方程式

HRID 1753056 的结构方程式

REACTANTS

反应物

3
结构：CC(C)I
HCID6362

2-Iodopropane

C3H7I

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Fc1cncc2c(Br)c[nH]c12
HCID53412607

3-Bromo-7-fluoro-1H-pyrrolo[3,2-c]pyridine

C7H4BrFN2

PRODUCTS

生成物

1
结构：CC(C)n1cc(Br)c2cncc(F)c21
HCID90093605

未命名化合物

收率 56%

PROCEDURE

实验过程

Prepared according to the method described for Preparation 45 using 3-bromo-7-fluoro-1H-pyrrolo[3,2-c]pyridine (Preparation 48), 2-iodopropane and potassium carbonate as base. Purified using silica gel column chromatography eluting with 100% heptanes to 50:50 Heptane:EtOAc to afford the title compound (845 mg, 56%).

WORKUP

后处理

  1. customPrepared
  2. customPurified
  3. washeluting with 100% heptanes to 50:50 Heptane