Isopropyl iodide → HCID 90093605, compound

HRID 1753056Notes

Reaction equation

HRID 1753056 reaction equation
[Br:1][C:2]1[C:6]2[CH:7]=[N:8][CH:9]=[C:10]([F:11])[C:5]=2[NH:4][CH:3]=1.I[CH:13]([CH3:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>>[Br:1][C:2]1[C:6]2[CH:7]=[N:8][CH:9]=[C:10]([F:11])[C:5]=2[N:4]([CH:13]([CH3:15])[CH3:14])[CH:3]=1

Participants

4

Reactant 3

HCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 534126073-bromo-7-fluoro-1H-pyrrolo[3,2-c]pyridine

Product 1

HCID 90093605HCID 90093605, compoundYield 56%

Procedure

Prepared according to the method described for Preparation 45 using 3-bromo-7-fluoro-1H-pyrrolo[3,2-c]pyridine (Preparation 48), 2-iodopropane and potassium carbonate as base. Purified using silica gel column chromatography eluting with 100% heptanes to 50:50 Heptane:EtOAc to afford the title compound (845 mg, 56%).

Workup

  1. customPrepared
  2. customPurified
  3. washeluting with 100% heptanes to 50:50 Heptane

Sources & evidence

ORD record
ord-651c583086984c52905f0f248aae33ea
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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