反应详情

To a solution of 1-Isopropyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ethyl ester (Preparation 111, 10.2 g, 40.76 mmol) in toluene (200 mL) at −78° C. was added DIBALH (85 mL, 101.91 mmol) dropwise and the reaction allowed to stir at this temperature for 2 hours. 2N HCl was added to quench the reaction followed by extraction into EtOAc. The organic layer was collected, washed with water, brine, dried over sodium sulphate and concentrated in vacuo to afford the title compound (8.3 g) that was taken directly on to the next step.

1. customto quench the reaction
2. extractionfollowed by extraction into EtOAc
3. customThe organic layer was collected
4. washwashed with water, brine
5. dry with materialdried over sodium sulphate
6. concentrationconcentrated in vacuo