2-Methyl-3-pentanone → 1-(Dimethylamino)-2,4-dimethylpent-1-en-3-one

HRID 1753111Notes

Reaction equation

HRID 1753111 reaction equation
[CH3:1][CH:2]([C:4](=[O:7])[CH2:5][CH3:6])[CH3:3].[CH3:8][N:9]([CH:11](OC)OC)[CH3:10]>>[CH3:10][N:9]([CH3:8])/[CH:11]=[C:5](\[CH3:6])/[C:4](=[O:7])[CH:2]([CH3:3])[CH3:1]

Participants

3

Reactant 2

HCID 112652-Methyl-3-pentanoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 772303151-(Dimethylamino)-2,4-dimethylpent-1-en-3-one

Procedure

2-Methyl-3-pentanone (5 g, 49.9 mmol) and DMF-DMA (10 mL, 74.9 mmol) were heated together in a sealed tube for 4 days. The reaction was concentrated in vacuo to afford an orange oil that was used directly in the next reaction (1.64 g, 21%).

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customto afford an orange oil that
  3. customwas used directly in the next reaction (1.64 g, 21%)

Sources & evidence

ORD record
ord-48abf196fa1645838d9ff75f016dce50
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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