Hydrochloric Acid → HCID 83636313, compound

HRID 1753112Notes

Reaction equation

HRID 1753112 reaction equation
[CH:1]([C:4]1[CH:8]=[C:7]([CH3:9])[N:6]([CH2:10][C:11]([O:13]CC)=[O:12])[N:5]=1)([CH3:3])[CH3:2].[Li+].[OH-].Cl>O>[CH:1]([C:4]1[CH:8]=[C:7]([CH3:9])[N:6]([CH2:10][C:11]([OH:13])=[O:12])[N:5]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 70847751Ethyl 2-(3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetate

Product 1

HCID 83636313HCID 83636313, compoundYield 66.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of ethyl (3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetate (Preparation 129, 571 mg, 2.72 mmol) and LiOH (342 mg, 8.15 mmol) in IMS (5 mL) and water (4 mL) was stirred at room temperature for 30 minutes. The reaction was acidified with 2M HCl and extracted with EtOAc. The organic layer was collected, washed with brine, dried over MgSO4 and concentrated in vacuo to afford the title compound as a cream solid (328 mg, 66%).

Workup

  1. extractionextracted with EtOAc
  2. customThe organic layer was collected
  3. washwashed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-82227e3321884828bf8997111878a266
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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