Dimethylformamide → N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-1-methyl-3-oxo-2-phenyl-5-(pyrrolidin-1-ylmethyl)-2,3-dihydro-1H-pyrazole-4-carboxamide

HRID 175332Notes

Reaction equation

HRID 175332 reaction equation
[CH2:43]([N:44]([CH:45]([CH3:46])[CH3:47])[CH:48]([CH3:49])[CH3:50])[CH3:51].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([O:13][c:14]3[cH:15][cH:16][c:17]([NH2:20])[n:18][cH:19]3)[cH:8][cH:9][n:10][c:11]2[cH:12]1.[CH3:21][n:22]1[n:23](-[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:24](=[O:36])[c:25]([C:33](=[O:34])[OH:35])[c:26]1[CH2:27][N:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1.[O:76]=[CH:77][N:78]([CH3:79])[CH3:80].[P-:52]([F:53])([F:54])([F:55])([F:56])([F:57])[F:58].[n:59]1([O:60][C:61]([N:62]([CH3:63])[CH3:64])=[N+:65]([CH3:66])[CH3:67])[c:68]2[n:69][cH:70][cH:71][cH:72][c:73]2[n:74][n:75]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([O:13][c:14]3[cH:15][cH:16][c:17]([NH:20][C:33]([c:25]4[c:24](=[O:36])[n:23](-[c:37]5[cH:38][cH:39][cH:40][cH:41][cH:42]5)[n:22]([CH3:21])[c:26]4[CH2:27][N:28]4[CH2:29][CH2:30][CH2:31][CH2:32]4)=[O:34])[n:18][cH:19]3)[cH:8][cH:9][n:10][c:11]2[cH:12]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 595983945-(7-Methoxyquinolin-4-yloxy)pyridin-2-amineHCID 595984571-methyl-3-oxo-2-phenyl-5-(pyrrolidin-1-ylmethyl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Product 1

HCID 11947782N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-1-methyl-3-oxo-2-phenyl-5-(pyrrolidin-1-ylmethyl)-2,3-dihydro-1H-pyrazole-4-carboxamide

Sources & evidence

ORD record
ord-90b8e799e79744c8949ef9fdd0aadd53
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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