Hydrochloric Acid → HCID 67979862, compound

HRID 1753697Notes

Reaction equation

HRID 1753697 reaction equation
C([O:3][C:4]([C:6]1[S:31][C:9]2[C:10]3[S:15][CH:14]=[C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:11]=3[S:12][C:8]=2[C:7]=1[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])=[O:5])C.[OH-].[Na+].O.Cl>CCO>[CH2:32]([C:7]1[C:8]2[S:12][C:11]3[C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:14][S:15][C:10]=3[C:9]=2[S:31][C:6]=1[C:4]([OH:5])=[O:3])[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 67979692HCID 67979692, compound

Product 1

HCID 67979862HCID 67979862, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5 (4.2 g, 6.1 mmol) and NaOH (0.49 g, 12.2 mmol) in EtOH (80 mL) was refluxed for 6 h. The mixture was poured into water (400 mL). The pH was adjusted to 1 with aqueous 10 M HCl solution. The precipitated solid was collected by filtration and dried under vacuum. The crude product was used for the next step without any purification (3.9 g, 98% yield).

Workup

  1. temperaturewas refluxed for 6 h
  2. filtrationThe precipitated solid was collected by filtration
  3. customdried under vacuum
  4. customThe crude product was used for the next step without any purification (3.9 g, 98% yield)

Sources & evidence

ORD record
ord-fda67bd7f02f40a9ae0561adc02bfe3a
Source dataset
uspto-grants-2015_10
Patent number
US09166167B2

Reaction notes

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