Hydrochloric Acid → HCID 67457458, compound

HRID 1753841Notes

Reaction equation

HRID 1753841 reaction equation
[ClH:1].FC(F)(F)C(O)=O.[CH3:9][C:10]1[C:15]([CH3:16])=[CH:14][N:13]=[C:12]([N:17]2[C:21](=[O:22])[C:20]([N:23]3[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[N:25]=[CH:24]3)=[CH:19][NH:18]2)[CH:11]=1>O1CCOCC1>[ClH:1].[CH3:9][C:10]1[C:15]([CH3:16])=[CH:14][N:13]=[C:12]([N:17]2[C:21](=[O:22])[C:20]([N:23]3[CH:27]=[C:26]([C:28]([F:30])([F:31])[F:29])[N:25]=[CH:24]3)=[CH:19][NH:18]2)[CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86648148HCID 86648148, compound

Product 1

HCID 67457458HCID 67457458, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.5 ml of a 4 N solution of hydrogen chloride in dioxane are added to 80 mg (0.2 mmol) of the compound from Example 94 and the mixture is stirred at RT for 1 h. The solid is filtered off, washed in each case once with dioxane and tert-butyl methyl ether and subsequently dried under a high vacuum.

Workup

  1. filtrationThe solid is filtered off
  2. washwashed in each case once with dioxane and tert-butyl methyl ether
  3. customsubsequently dried under a high vacuum

Sources & evidence

ORD record
ord-0348170f75554c0a8ae4f655fb4cd426
Source dataset
uspto-grants-2015_10
Patent number
US09168249B2

Reaction notes

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