反应详情

温度

120 °C

To a stirred mixture of 2.50 g (13 mmol) 2-bromo-5-hydroxy-benzonitrile in 100 mL DMF are added 5.23 g (38 mmol) K2CO3 and 3.05 g (25 mmol) cyclopropylbromide. The reaction mixture is stirred for 16 h at 120° C. Afterwards the reaction is quenched by the addition of ice water and extracted with EtOAc. The org. layers are combined, washed with sat. aq. NaCl solution, dried over Na2SO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc).

1. customAfterwards the reaction is quenched by the addition of ice water
2. extractionextracted with EtOAc
3. washwashed with sat. aq. NaCl solution
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customthe solvent is removed in vacuo
7. customThe crude product is purified by column chromatography (silica gel, PE/EtOAc)