反应详情

温度

80 °C

A mixture of 0.350 g (1.13 mmol) of 1-[3-(methylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile (Preparation 1) and methyl benzenecarboximidoate hydrochloride (0.213 g, 1.24 mmol, 1.1 equiv.) in 0.7 mL of N-methyl-pyrrolidinone was treated with potassium carbonate (0.11 g, 0.79 mmol, 0.7 equiv.) and heated to 80° C. for 15 hr. The solvent was then removed and the crude product purified by column chromatography to give the title compound 0.096 g (19%) as a white solid.

1. customThe solvent was then removed
2. customthe crude product purified by column chromatography