反应详情

A suspension of ethyl 7-bromo-2,4-dioxo-1-(propan-2-yl)-1,2,3,4-tetrahydroquinoline-3-carboxylate (1.5 g, 4.23 mmol) in sodium hydroxide (2M solution, 32 mL, 64 mmol) is heated to reflux. The reaction medium becomes homogeneous and, after 3 hours, a suspension is once again observed. 6 mL of NMP are added to homogenize, and the resulting mixture is than refluxed for 12 hours. The solution cooled to room temperature is poured into 6M hydrochloric acid solution to give a white precipitate, which is filtered off. After rinsing with water and drying the precipitate under vacuum, 1.1 g of a white solid are obtained (yield: 91%).

1. temperatureis heated to reflux
2. temperaturethan refluxed for 12 hours
3. customto give a white precipitate, which
4. filtrationis filtered off
5. washAfter rinsing with water
6. dry with materialdrying the precipitate under vacuum, 1.1 g of a white solid
7. customare obtained (yield: 91%)