Hydrochloric Acid → HCID 89454054, compound

HRID 1754566Notes

Reaction equation

HRID 1754566 reaction equation
[F:1][C:2]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[CH:10][C:9]2[N:8]([CH2:18][C:19]([F:22])([F:21])[F:20])[C:7](=[O:23])[C:6]3[CH2:24][N:25](C4CCCCO4)[NH:26][C:5]=3[C:4]=2[CH:3]=1.[ClH:33]>O1CCOCC1>[ClH:33].[F:1][C:2]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[CH:10][C:9]2[N:8]([CH2:18][C:19]([F:21])([F:22])[F:20])[C:7](=[O:23])[C:6]3[CH:24]=[N:25][NH:26][C:5]=3[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 86730104HCID 86730104, compound

Product 1

HCID 89454054HCID 89454054, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. by treating 8-fluoro-7-(pyrid-2-yl)-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one with HCl in dioxane (4M). It is in the form of a white powder (hydrochloride; yield 75%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-adc6b75b5e3044aeac8d17bc7e2cae47
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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