Hydrochloric Acid → HCID 86679813, compound

HRID 1754569Notes

Reaction equation

HRID 1754569 reaction equation
[Cl:1][C:2]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[CH:10][C:9]2[N:8]([CH2:18][C:19]([F:22])([F:21])[F:20])[C:7](=[O:23])[C:6]3[CH:24]=[N:25][NH:26][C:5]=3[C:4]=2[CH:3]=1.Cl.O1CCOCC1>C(Cl)Cl.CO>[ClH:1].[Cl:1][C:2]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[CH:10][C:9]2[N:8]([CH2:18][C:19]([F:21])([F:22])[F:20])[C:7](=[O:23])[C:6]3[CH:24]=[N:25][NH:26][C:5]=3[C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71558644HCID 71558644, compound

Product 1

HCID 86679813HCID 86679813, compoundYield 144.5%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

To a solution of 8-chloro-7-(pyrid-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one (532 mg, 1.40 mmol) in a DCM/MeOH mixture (50/50) is added a 4M solution of hydrogen chloride in dioxane (3.5 mL, 14.1 mmol). The suspension is stirred at room temperature and then filtered and dried under vacuum to give 420 mg of a white powder (hydrochloride, 0.06 H2O; yield: 72%)

Workup

  1. filtrationfiltered
  2. customdried under vacuum

Sources & evidence

ORD record
ord-3e4684c28afc40288f22c54792808d81
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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