Hydrochloric Acid → HCID 89454181, compound

HRID 1754570Notes

Reaction equation

HRID 1754570 reaction equation
N1C=CC=CC=1C1C2C(=O)N(CC(F)(F)F)C3C=CC=CC=3C=2N(C2CCCCO2)N=1.[Br:32][C:33]1[C:42]([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][N:44]=2)=[CH:41][C:40]2[N:39]([CH2:49][C:50]([F:53])([F:52])[F:51])[C:38](=[O:54])[C:37]3[CH2:55][N:56](C4CCCCO4)[NH:57][C:36]=3[C:35]=2[CH:34]=1.[ClH:64].O>O1CCOCC1>[ClH:64].[Br:32][C:33]1[C:42]([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][N:44]=2)=[CH:41][C:40]2[N:39]([CH2:49][C:50]([F:52])([F:53])[F:51])[C:38](=[O:54])[C:37]3[CH:55]=[N:56][NH:57][C:36]=3[C:35]=2[CH:34]=1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 89454041HCID 89454041, compoundHCID 131733668HCID 131733668, compound

Product 1

HCID 89454181HCID 89454181, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. by treating 8-bromo-7-(pyrid-2-yl-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 8-bromo-7-(pyrid-2-yl)-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one with 4M HCl in dioxane, in the form of a white powder (hydrochloride, 0.4 H2O; yield 94%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-4aed1ec2ed3f4e45ba937318719d0bb9
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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