Ethylene Glycol → Tert-butyl 4-(5-bromopyridin-3-yl)piperazine-1-carboxylate

HRID 175473Notes

Reaction equation

HRID 175473 reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][c:6]([I:8])[cH:7]1.[CH2:30]([OH:31])[CH2:32][OH:33].[CH:34]([OH:35])([CH3:36])[CH3:37].[Cu:38][I:39].[K+:27].[K+:28].[K+:29].[N:9]1([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1.[P:22]([O-:23])([O-:24])([O-:25])=[O:26]>>[Br:1][c:2]1[cH:3][n:4][cH:5][c:6]([N:12]2[CH2:11][CH2:10][N:9]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:14][CH2:13]2)[cH:7]1

Participants

8

Reactant 7

HCID 174Ethylene GlycolHCID 813Potassium Cation3×HCID 1061PhosphateHCID 3776IsopropanolHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 143452tert-Butyl piperazine-1-carboxylateHCID 8204093-Bromo-5-iodopyridine

Product 1

HCID 11653049Tert-butyl 4-(5-bromopyridin-3-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-2b50aa84943a4217b09f1bf7bd5d463e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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