Dichloromethane → 5-(Triphenylmethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 1754807Notes

Reaction equation

HRID 1754807 reaction equation
C(N(CC)CC)C.ClCCl.[S:11]1[C:19]2[CH2:18][CH2:17][NH:16][CH2:15][C:14]=2[CH:13]=[CH:12]1.[C:20](Cl)([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O>[C:20]([N:16]1[CH2:17][CH2:18][C:19]2[S:11][CH:12]=[CH:13][C:14]=2[CH2:15]1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6456Trityl chlorideHCID 8471TriethylamineHCID 30850764,5,6,7-Tetrahydrothieno(3,2-c)pyridine

Product 1

HCID 137484615-(Triphenylmethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

23 cm3 (0.083 mol) of triethyl-amine are added to the solution of 23 cm3 of dichloro methane and 11.5 g (0.083 mol) 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine dropwise at room temperature and 23 g (0.083 mol) of trityl-chloride are further added to the mixture. The reaction mixture is kept at room temperature for one night and poured onto 2000 ml of water. The organic phase is separated, dried with sodium sulfate and evaporated. The colorless, paste-like crystals are dried in vacuo for 5 hours at 80° C. under 140 mbar pressure.

Workup

  1. waitThe reaction mixture is kept at room temperature for one night
  2. customThe organic phase is separated
  3. dry with materialdried with sodium sulfate
  4. customevaporated
  5. customare dried in vacuo for 5 hours at 80° C. under 140 mbar pressure

Sources & evidence

ORD record
ord-e5cd0a862c44413cad0fed7e610db3ee
Source dataset
uspto-grants-2015_10
Patent number
US09169265B2

Reaction notes

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