4-Nitrobenzyl chloride → HCID 71677842, compound

HRID 1754813Notes

Reaction equation

HRID 1754813 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][Cl:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[O:12]1[CH:16]2[O:17][CH2:18][CH2:19][N:15]2[CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[Cl-:9].[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][N+:15]23[CH2:19][CH2:18][O:17][CH:16]2[O:12][CH2:13][CH2:14]3)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 74824-Nitrobenzyl chlorideHCID 798431-Aza-4,6-dioxabicyclo(3.3.0)octane

Product 1

HCID 71677842HCID 71677842, compoundYield 75.4%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 1.716 g (10 mmol) 4-nitrobenzyl chloride and 1.152 g (10 mmol) tetrahydro-[1,3]oxazolo[2,3-b][1,3]oxazole in 20 ml of chloroform was stirred at the room temperature for 3 days. The precipitate was filtered off, washed twice with dichloromethane and dried. 2.161 g (75.4%) of white amorphous product was obtained, which can be further purified by recrystallisation from rectified ethanol.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed twice with dichloromethane
  3. customdried

Sources & evidence

ORD record
ord-b90b7f3c5bca43a19b9dacd11221c3a1
Source dataset
uspto-grants-2015_10
Patent number
US09169267B2

Reaction notes

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