Hydrochloric Acid → (3,4-Dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methanol

HRID 175486Notes

Reaction equation

HRID 175486 reaction equation
[Al+3:60].[CH3:68][OH:69].[Cl:65][CH2:66][Cl:67].[ClH:1].[ClH:2].[H-:59].[H-:62].[H-:63].[H-:64].[Li+:61].[N+:37]([c:38]1[cH:39][cH:40][cH:41][cH:42][n:43]1)([O-:44])=[O:45].[NH2:3][CH:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH:9]2[n:10]3[c:11]4[n:12]([c:13](=[O:14])[cH:15][cH:16][c:17]4[cH:18][cH:19][c:20]3=[O:21])[CH2:22]2)[CH2:23][CH2:24]1.[O:46]=[C:47]1[CH2:48][S:49][c:50]2[cH:51][cH:52][c:53]([CH:54]=[O:55])[n:56][c:57]2[NH:58]1.[S:25]1[c:26]2[c:27]([n:31][c:32]([CH:35]=[O:36])[cH:33][cH:34]2)[NH:28][CH2:29][CH2:30]1>>[S:25]1[c:26]2[c:27]([n:31][c:32]([CH2:35][OH:36])[cH:33][cH:34]2)[NH:28][CH2:29][CH2:30]1

Participants

11

Reactant 10

HCID 313Hydrochloric Acid2×HCID 887MethanolHCID 6344DichloromethaneHCID 269982-NitropyridineHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 115935913-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehydeHCID 184545003,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehydeHCID 580017221-[(4-Amino-1-piperidinyl)methyl]-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

Product 1

HCID 18454501(3,4-Dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methanol

Sources & evidence

ORD record
ord-07ea08f9e87a4429bcd974085ca6ceb6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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