Methanol → HCID 23569579, compound
Reaction equation
Cl[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[CH3:11][NH2:12].CO.[I-].[Na+]>C(O)C>[CH3:11][NH:12][CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
2-[2-(2-Chloro-ethoxy)-ethoxy]-ethanol (2.00 mL, 13.8 mmol) was dissolved in ethanol (14.0 mL). A solution of methylamine in methanol (40%, 14.0 mL, 138 mmol) and sodium iodide (103 mg, 0.67 mmol) were added, and the mixture was stirred at 60° C. for 18 hours and then stirred at 75° C. for seven hours in a nitrogen atmosphere. The reaction solution was concentrated under reduced pressure to give 2-[2-(2-methylamino-ethoxy)-ethoxy]-ethanol as a crude product.
Workup
- stirringstirred at 75° C. for seven hours in a nitrogen atmosphere
- concentrationThe reaction solution was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-62886e1d40c4476a9773ba1b33493d9d
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09169254B2
Reaction notes
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