Hydrochloric Acid → HCID 86720549, compound

HRID 1755280Notes

Reaction equation

HRID 1755280 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]2[C:15]3[N:16]([CH:21]=[CH:22][CH:23]=3)[CH:17]=[C:18]([CH3:20])[N:19]=2)[CH2:10]1)(C)(C)C>CO>[ClH:1].[ClH:1].[CH3:20][C:18]1[N:19]=[C:14]([N:11]2[CH2:12][CH2:13][CH:9]([NH2:8])[CH2:10]2)[C:15]2[N:16]([CH:21]=[CH:22][CH:23]=2)[CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86720551HCID 86720551, compound

Product 1

HCID 86720549HCID 86720549, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HCl (4 M in dioxane, 3.80 mL, 15.2 mmol) was added to [1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (965 mg, 3.04 mmol) in MeOH (10 mL). This was stirred overnight then concentrated to give the product (860 mg, 2.97 mmol, 98%) as a white solid.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-eab593bbffbb4e47ae5e8a2b2b5b4397
Source dataset
uspto-grants-2015_10
Patent number
US09169261B2

Reaction notes

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