Trifluoroacetic acid → Trifluoroacetic acid

HRID 1755441Notes

Reaction equation

HRID 1755441 reaction equation
[CH:1]([C:3]1[S:7][C:6]([NH:8][CH2:9][C:10]([NH:12][C@@H:13]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:14]([O:16]C(C)(C)C)=[O:15])=[O:11])=[N:5][CH:4]=1)=[O:2].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>C(Cl)Cl>[CH:1]([C:3]1[S:7][C:6]([NH:8][CH2:9][C:10]([NH:12][C@@H:13]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:14]([OH:16])=[O:15])=[O:11])=[N:5][CH:4]=1)=[O:2].[C:30]([OH:32])([C:29]([F:34])([F:33])[F:28])=[O:31]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86700090HCID 86700090, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 86700091HCID 86700091, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of material from Example 10 (27 mg, 0.07 mmol) in CH2Cl2 (6 mL) is added trifluoroacetic acid (2.5 mL, 32.4 mmol). The resulting solution is stirred at room temperature for 1 h, then evaporated to dryness over 18 h to give the title compound as a TFA salt that is used crude, and in its entirety in the next step. LC/MS (Condition A): ret. T=2.45 min, (M+1-H)+ 334.08.

Workup

  1. customevaporated to dryness over 18 h

Sources & evidence

ORD record
ord-da5997be35ff40c3a047347b36578978
Source dataset
uspto-grants-2015_10
Patent number
US09169295B2

Reaction notes

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