1-Amino-2-propanol → HCID 67263072, compound

HRID 1755583Notes

Reaction equation

HRID 1755583 reaction equation
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([OH:16])=O)[CH2:6][CH2:5]2.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:31][CH2:32][CH:33]([OH:35])[CH3:34]>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([NH:31][CH2:32][CH:33]([OH:35])[CH3:34])=[O:16])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 41-Amino-2-propanolHCID 40634TroloxHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 67263072HCID 67263072, compoundYield 84.2%

Procedure

Following the amide coupling procedure described in protocol A, 4.98 g 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (19.9 mmol), 3.99 g CDI (24.6 mmol) and 3.01 g 3-amino-2-propanol (39.9 mmol), yielded 5.15 g of 6-hydroxy-N-(2-hydroxypropyl)-2,5,7,8-tetramethylchroman-2-carboxamide as a white powder.

Sources & evidence

ORD record
ord-2d8786dce4be463c823e86f46d4f0193
Source dataset
uspto-grants-2015_10
Patent number
US09169196B2

Reaction notes

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