Methylparaben → HCID 19917653, compound

HRID 1755606Notes

Reaction equation

HRID 1755606 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:13]([CH2:16][CH:17]=[CH2:18])[CH:14]=[CH2:15].[CH3:19][O:20][C:21]([C:23]1[CH:24]=[CH:25][C:26]([OH:29])=[CH:27][CH:28]=1)=[O:22].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:15]=[CH:14][CH:13]([O:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][O:29][C:26]1[CH:27]=[CH:28][C:23]([C:21]([O:20][CH3:19])=[O:22])=[CH:24][CH:25]=1)[CH2:16][CH:17]=[CH2:18]

Participants

5

Reactant 3

HCID 7456MethylparabenHCID 11430Potassium CarbonateHCID 19917651HCID 19917651, compound

Product 1

HCID 19917653HCID 19917653, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

10 g of the compound (1), 4.8 g of methyl p-hydroxybenzoate and 4.4 g of potassium carbonate were refluxed in 2-butanone for 12 hours. The insoluble matter generated was filtered off, and the solvent was evaporated. The residue was purified by column chromatography, to obtain 9.3 g of the objective compound (2). (Yield: 76%)

Workup

  1. filtrationThe insoluble matter generated was filtered off
  2. customthe solvent was evaporated
  3. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-716c5d2808dd448da8dd81d4551012d2
Source dataset
uspto-grants-1995_08
Patent number
US05437816

Reaction notes

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