反应详情

3 g of the compound (7), 1.5 g of methyl 4-hydroxybenzoate and 4.1 g of potassium carbonate were dissolved in 50 ml of 2-butanone, and reflux was carried out for 10 hours in an atmosphere of argon. After the precipitated solid matter was filtered off, the solvent was evaporated, and the residue was purified by a chromatography using a column filled with alumina and silica gel, to obtain 2.3 g of the compound (8). (Yield: 64%)

1. temperaturereflux
2. filtrationAfter the precipitated solid matter was filtered off
3. customthe solvent was evaporated
4. customthe residue was purified by a chromatography
5. additionfilled with alumina and silica gel