Hydrogen Bromide → HCID 19916763, compound

HRID 1756068Notes

Reaction equation

HRID 1756068 reaction equation
[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11].[CH3:12][C:13]1[CH:22]=[CH:21][C:16]([C:17](=[O:20])[CH2:18]Br)=[CH:15][CH:14]=1.Br>CC#N>[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:18][C:17]([C:16]3[CH:21]=[CH:22][C:13]([CH3:12])=[CH:14][CH:15]=3)=[O:20])[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 692722-Bromo-4'-methylacetophenoneHCID 125323872,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 19916763HCID 19916763, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2,3-dimethylpyrrolo[2,3-b]pyridine (0.16 g, 1.1 mmol) and p-methylphenacyl bromide (0.26 g, 1.2 mmol) in 4.5 ml CH3CN was warmed to reflux which was enough to initiate crystallisation of the product as a light yellow solid. The precipitate was isolated as described in example 27 furnishing 0.29 g (74%) pure hydrobromide.

Workup

  1. temperatureto reflux which
  2. customcrystallisation of the product as a light yellow solid
  3. customThe precipitate was isolated

Sources & evidence

ORD record
ord-45fa9973ee864dd5bd374d579276aa1b
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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