Formaldehyde → HCID 54204491, compound

HRID 1756145Notes

Reaction equation

HRID 1756145 reaction equation
[CH:1]([C:3]1[CH:8]=[C:7]([CH:9]=[CH2:10])[N:6]=[CH:5][N:4]=1)=[CH2:2].CC1C=[C:16](C)[N:15]=[CH:14]N=1.Cl.[CH3:20][NH:21][CH3:22].C=O>O>[CH3:20][N:21]([CH2:2][CH2:1][C:3]1[CH:8]=[C:7]([CH2:9][CH2:10][N:15]([CH3:14])[CH3:16])[N:6]=[CH:5][N:4]=1)[CH3:22]

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 152574,6-DimethylpyrimidineHCID 19349509HCID 19349509, compound

Product 1

HCID 54204491HCID 54204491, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound 4,6-divinylpyrimidine is miscible with water and can be prepared according to the synthetic scheme illustrated in FIG. 1. As shown, in a two-step process, 4,6-dimethylpyrimidine is reacted with dimethylamine hydrochloride and formaldehyde to provide the corresponding 4,6-bis(dimethylaminoethyl)pyrimidine. This dimethylaminoethyl compound is methylated and deaminated in the presence of a base to provide the desired 4,6-divinylpyrimidine.

Workup

  1. customcan be prepared

Sources & evidence

ORD record
ord-aa7cd33d6fbe49b48c4538b4afadb04c
Source dataset
uspto-grants-1995_08
Patent number
US05439950

Reaction notes

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