Ethyl bromoacetate → HCID 19917140, compound

HRID 1756175Notes

Reaction equation

HRID 1756175 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][OH:7])=[CH:2]1.[H-].[Na+].Br[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]>CN(C)C=O>[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][O:7][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:2]1

Participants

5

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 123570Thiophene-3-methanol

Product 1

HCID 19917140HCID 19917140, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.0 g of 3-thiophenemethanol was dissolved in 6 ml of dimethylformamide, and under ice cooling, 0.36 g of 60% oily sodium hydride and 1 ml of ethyl bromoacetate were added. The mixture was stirred at room temperature for 15 hours, and then worked up in a customary manner. The product was purified by silica gel column chromatography [hexane/ethyl acetate=6/1] to give 0.9 g of ethyl 3-thienylmethoxyacetate as a colorless oil.

Workup

  1. customThe product was purified by silica gel column chromatography [hexane/ethyl acetate=6/1]

Sources & evidence

ORD record
ord-dba3ff5e4797434dac60d81498edeee6
Source dataset
uspto-grants-1995_08
Patent number
US05439932

Reaction notes

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