Lithium Hydroxide → HCID 15341821, compound

HRID 1756209Notes

Reaction equation

HRID 1756209 reaction equation
[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[C:6]([CH2:31][CH2:32][CH3:33])[C:5]=1[O:34][CH3:35])=[O:3].[OH-].[Li+]>CO>[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:6]([CH2:31][CH2:32][CH3:33])[C:5]=1[O:34][CH3:35])=[O:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 15341820HCID 15341820, compound

Product 1

HCID 15341821HCID 15341821, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 42 (90 mg, 0.1845 mmol) and 369 μl of 1M lithium hydroxide were added to 2.0 ml of methanol, and the reaction mixture was stirred at room temperature overnight. The solvent was removed under vacuum, 10 ml of water was added, and the solution was acidified with dilute hydrochloric acid then stirred for 1 hour. The white precipitate that formed was removed by filtration and dried at 40° C. in a vacuum oven to give the product.

Workup

  1. customThe solvent was removed under vacuum, 10 ml of water
  2. additionwas added
  3. stirringthen stirred for 1 hour
  4. customThe white precipitate that formed
  5. customwas removed by filtration
  6. customdried at 40° C. in a vacuum oven
  7. customto give the product

Sources & evidence

ORD record
ord-35d40925db834fd8abc3408fa79c641d
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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