Hydrochloric Acid → HCID 15341831, compound

HRID 1756216Notes

Reaction equation

HRID 1756216 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH2:34][CH:35]=[CH2:36])=[C:5]([CH:27]=[CH:28][C:29]=1[C:30]([NH:32][CH3:33])=[O:31])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([CH2:24][CH2:25][CH3:26])=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([O:18]CC)=[O:17].[OH-].[Li+].CO.Cl>O>[CH3:1][O:2][C:3]1[C:4]([CH2:34][CH:35]=[CH2:36])=[C:5]([CH:27]=[CH:28][C:29]=1[C:30]([NH:32][CH3:33])=[O:31])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([CH2:24][CH2:25][CH3:26])=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([OH:18])=[O:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 15341830HCID 15341830, compound

Product 1

HCID 15341831HCID 15341831, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound of Example 52 (95 mg, 0.19 mmol) and 380 μl (0.38 mmol) of 1M lithium hydroxide were added to 2.0 ml of methanol, and the reaction mixture was stirred for four hours at room temperature. The solvent was removed under vacuum to give a white solid which was suspended in 5.0 ml of water. The mixture was acidified with 10% hydrochloric acid, stirred and filtered to remove the resultant solid which was then dried at 40° C. overnight in a vacuum oven to give the product.

Workup

  1. customThe solvent was removed under vacuum
  2. customto give a white solid which
  3. stirringstirred
  4. filtrationfiltered
  5. customto remove the resultant solid which
  6. customwas then dried at 40° C. overnight in a vacuum oven
  7. customto give the product

Sources & evidence

ORD record
ord-326f00f7ebd3402ca817b28ca67dc09f
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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