反应详情

1.65 g (55 mmol) of sodium hydride (80% in oil ) and 50 ml of DMF are introduced under a stream of nitrogen into a round-bottomed flask. 8.2 g (50 mmol) of 4-acetylbenzoic acid, dissolved in 100 ml of DMF, are added dropwise and the mixture is stirred at room temperature until gaseous evolution has ceased. 4.6 ml (55 mmol) of allyl bromide are then introduced and the mixture is stirred at room temperature for 24 hours. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, then dried over magnesium sulphate and evaporated. The residue obtained is purified by chromatography on a silica column, eluting with a mixture of dichloromethane and hexane (80:20). After evaporation of the solvents, 7.2 g (71 % ) of allyl ester are collected in the form of a colorless oil.

1. additionare added dropwise
2. stirringthe mixture is stirred at room temperature for 24 hours
3. extractionthe mixture is extracted with ethyl ether
4. customthe organic phase is separated after settling
5. dry with materialdried over magnesium sulphate
6. customevaporated
7. customThe residue obtained
8. customis purified by chromatography on a silica column
9. washeluting with a mixture of dichloromethane and hexane (80:20)
10. customAfter evaporation of the solvents, 7.2 g (71 % ) of allyl ester
11. customare collected in the form of a colorless oil