Hydrochloric Acid → 4-(Hydroxymethyl)benzaldehyde

7.9 g (44 mmol) of the above alcohol and 100 ml of THF are introduced into a round-bottomed flask, 20 ml of hydrochloric acid (1N) are added and the mixture is heated to reflux for 4 h. The reaction medium is evaporated to dryness, the residue is taken up with ethyl ether and saturated sodium bicarbonate solution and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated.

1. temperaturethe mixture is heated
2. temperatureto reflux for 4 h
3. customThe reaction medium is evaporated to dryness
4. customthe organic phase is separated after settling
5. dry with materialdried over magnesium sulphate
6. customevaporated

ORD record

ord-a4f55a1d491a44a09d9055a9a6a30b46

Source dataset

uspto-grants-1995_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05439925